Exercises
Define sliding filament theory of muscle contraction.
The sliding filament theory states that muscle contraction occurs by the sliding of thin filaments (actin) over thick filaments (myosin), without any change in the length of either filament.
Key points of the theory:
- During contraction, actin thin filaments slide towards the centre of the A band (towards the M line)
- The Z lines, to which thin filaments are attached, are pulled inward, shortening the sarcomere
- The I bands get reduced (shorten) as actin slides in
- The H zone narrows as thin filaments cover more of the thick filaments
- The A band length remains constant throughout contraction
- Energy from ATP hydrolysis powers the cyclic formation and breaking of cross bridges between myosin heads and actin
Answer: The sliding filament theory states that muscle contraction occurs by the sliding of thin (actin) filaments over thick (myosin) filaments. During contraction, actin slides toward the M line, the I bands shorten, the H zone narrows, but the A band length remains unchanged.
